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Proteintech
TCF12 Monoclonal Antibody (1B8D4), CoraLite® Plus 488
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TCF12 Antibody (CL488-67523) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human TCF12 (CL488-67523, Clone:1B8D4) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL488-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
产品信息
CL488-67523
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
1B8D4
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: SNPSTPVGSP SPLTGTSQWP RPGGQAPSSP SYENSLHSLK NRVEQQLHEH LQDAMSFLKD VCEQSRMEDR LDRLDDAIHV LRNHAVGPST SLPAGHSDIH SLLGPSHNAP IGSLNSNYGG SSLVASSRSA SMVGTHREDS VSLNGNHSVL SSTVTTSSTD LNHKTQENYR GGLQSQSGTV VTTEIKTENK EKDENLHEPP SSDDMKSDDE SSQKDIKVSS RGRTSSTNED EDLNPEQKIE REKERRMANN ARERLRVRDI NEAFKELGRM CQLHLKSEKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSAVSAEPPT TLPGTHPGLS ETTNPMGHM
靶标信息
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb20; Class A helix-loop-helix transcription factor ME1; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; helix-loop-helix transcription factor 4; Salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBP-alpha; TCF-12; Transcription factor 12; Transcription factor HTF-4
基因别名: A130037E08Rik; ALF1; BHLHB20; CRS3; HEB; HEBAlt; HsT17266; HTF-4; HTF4; ME1; Meb; REB; SCBPA; TCF-12; TCF12
UniProt ID: (Human) Q99081, (Mouse) Q61286, (Rat) P51514
Entrez Gene ID: (Human) 6938, (Mouse) 21406, (Rat) 25720
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enhancer binding
cAMP response element binding
protein homodimerization activity
bHLH transcription factor binding
transcription regulatory region DNA binding
SMAD binding
protein heterodimerization activity
E-box binding
HMG box domain binding
DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
immune response
muscle organ development
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
positive regulation of gene expression
cell differentiation
positive regulation of transcription, DNA-templated
