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Proteintech
VAMP2 Monoclonal Antibody (1G7E8), CoraLite® Plus 488
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Product Details
CL488-67822
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
1G7E8
Immunogen
VAMP2 fusion protein Ag17908
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSATAATAP PAAPAGEGGP PAPPPNLTSN RRLQQTQAQV DEVVDIMRVN VDKVLERDQK LSELDDRADA LQAGASQFET SAAKLKRKYW WKNLKMMIIL GVICAIILII IIVYFST
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; Synaptobrevin-2; vamp; VAMP-2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
Gene Aliases: RATVAMPB; RATVAMPIR; SYB; Syb-2; SYB2; sybII; VAMP-2; VAMP2
UniProt ID: (Human) P63027, (Mouse) P63044, (Rat) P63045
Entrez Gene ID: (Rabbit) 100008775, (Pig) 100620549, (Human) 6844, (Mouse) 22318, (Rat) 24803
protein complex assembly
vesicle fusion
response to glucose
protein transport
synaptic vesicle exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
cellular response to insulin stimulus
Golgi to plasma membrane protein transport
eosinophil degranulation
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
neurotransmitter secretion
neutrophil degranulation
natural killer cell degranulation
mucus secretion
regulation of histamine secretion by mast cell
exocytosis
post-Golgi vesicle-mediated transport
glutamate secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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