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Proteintech
AIFM2/FSP1 Monoclonal Antibody (1A2B2), CoraLite® Plus 488
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FIGURE: 1 / 1
AIFM2/FSP1 Antibody (CL488-68049) in Flow
1X10^6 K-562 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human AIFM2 (CL488-68049, Clone:1A2B2) (red), or 0.4 µg Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-68049
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2B2
Immunogen
Recombinant protein
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MGSQVSVESG ALHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV AALRASVETG FAKKTFISYS VTFKDNFRQG LVVGIDLKNQ MVLLQGGEAL PFSHLILATG STGPFPGKFN EVSSQQAAIQ AYEDMVRQVQ RSRFIVVVGG GSAGVEMAAE IKTEYPEKEV TLIHSQVALA DKELLPSVRQ EVKEILLRKG VQLLLSERVS NLEELPLNEY REYIKVQTDK GTEVATNLVI LCTGIKINSS AYRKAFESRL ASSGALRVNE HLQVEGHSNV YAIGDCADVR TPKMAYLAGL HANIAVANIV NSVKQRPLQA YKPGALTFLL SMGRNDGVGQ ISGFYVGRLM VRLTKSRDLF VSTSWKTMRQ SPP
Target Information
The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMID; apoptosis inducing factor mitochondria associated 2; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like flavoprotein; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; ferroptosis suppressor 1; Ferroptosis suppressor protein 1; FSP1; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; PRG3; p53-inducible; apoptotic protein; RP11-367H5.2; unnamed protein product
Gene Aliases: 5430437E11Rik; AIFM2; AMID; D730001I10Rik; FSP1; PRG3
UniProt ID: (Human) B3KXI0, (Mouse) Q8BUE4
Entrez Gene ID: (Human) 84883, (Mouse) 71361
DNA binding
electron-transferring-flavoprotein dehydrogenase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
flavin adenine dinucleotide binding
NADH dehydrogenase (ubiquinone) activity
N-ethylmaleimide reductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
epoxyqueuosine reductase activity
oxidoreductase
metabolite interconversion enzyme
ubiquinone metabolic process
apoptotic mitochondrial changes
respiratory electron transport chain
vitamin K metabolic process
positive regulation of apoptotic process
negative regulation of ferroptosis
regulation of cellular response to oxidative stress
cellular detoxification
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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