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Proteintech
DGAT2 Recombinant Rabbit Monoclonal Antibody (240171C6), CoraLite® Plus 488
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Product Details
CL488-83262-2
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
240171C6
Immunogen
DGAT2 fusion protein Ag10719
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: DWNTPKKGGR RSQWVRNWAV WRYFRDYFPI QLVKTHNLLT TRNYIFGYHP HGIMGLGAFC NFSTEATEVS KKFPGIRPYL ATLAGNFRMP VLREYLMSGG ICPVSRDTID YLLSKNGSGN AIIIVVGGAA ESLSSMPGKN AVTLRNRKGF VKLALRHGAD LVPIYSFGEN EVYKQVIFEE GSWGRWVQKK FQKYIGFAPC IFHGRGLFSS DTWGLVPYSK PITTVVGEPI TIPKLEHPTQ QDIDLYHTMY MEALVKLFDK HKTKFGLPET EVLEVN
Target Information
Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; DGAT-2; Diacylglycerol O-acyltransferase 2; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2; Diglyceride acyltransferase 2; DKFZp686A15125; GS1999full
Gene Aliases: ARAT; DGAT2; GS1999FULL; HMFN1045; UNQ738/PRO1433
UniProt ID: (Human) Q96PD7
Entrez Gene ID: (Human) 84649
glycerol metabolic process
lipid metabolic process
monoacylglycerol biosynthetic process
diacylglycerol biosynthetic process
response to nutrient
positive regulation of triglyceride biosynthetic process
triglyceride biosynthetic process
lipid storage
low-density lipoprotein particle clearance
long-chain fatty-acyl-CoA metabolic process
cellular triglyceride homeostasis
retinol metabolic process
cholesterol homeostasis
positive regulation of gluconeogenesis
negative regulation of fatty acid oxidation
diacylglycerol metabolic process
regulation of lipoprotein metabolic process
fatty acid homeostasis
fat pad development
cellular response to oleic acid
regulation of cholesterol metabolic process
regulation of plasma lipoprotein particle levels
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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