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Proteintech
GDF5 Recombinant Rabbit Monoclonal Antibody (240944E5), CoraLite® Plus 488
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产品信息
CL488-83988-4
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
240944E5
抗原
GDF5 fusion protein Ag6238
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1000 µg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: SFLLKKAREP GPPREPKEPF RPPPITPHEY MLSLYRTLSD ADRKGGNSSV KLEAGLANTI TSFIDKGQDD RGPVVRKQRY VFDISALEKD GLLGAELRIL RKKPSDTAKP AAPGGGRAAQ LKLSSCPSGR QPASLLDVRS VPGLDGSGWE VFDIWKLFRN FKNSAQLCLE LEAWERGRAV DLRGLGFDRA ARQVHEKALF LVFGRTKKRD LFFNEIKARS GQDDKTVYEY LFSQRRKRRA PLATRQGKRP SKNLKARCSR KALHVNFKDM GWDDWIIAPL EYEAFHCEGL CEFPLRSHLE PTNHAVIQTL MNSMDPESTP PTCCVPTRLS PISILFIDSA NNVVYKQYED MVVESCGCR
靶标信息
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP-14; Bone morphogenetic protein 14; brachypodism; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
基因别名: BDA1C; BMP-14; BMP14; Bp; brp; Cdmp-1; CDMP1; Gdf-5; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026, (Mouse) P43027
Entrez Gene ID: (Human) 8200, (Mouse) 14563
chondrocyte differentiation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
growth
regulation of multicellular organism growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
cell development
negative regulation of epithelial cell proliferation
SMAD protein signal transduction
chondroblast differentiation
mitophagy in response to mitochondrial depolarization
negative regulation of mesenchymal cell apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
BMP signaling pathway
cartilage development
