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Proteintech

Phospho-GSK3B (Ser9) Monoclonal Antibody (1C9E2), CoraLite® 594

View all (47) GSK3B antibodies

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Product Details

CL59467558100UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1C9E2

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.11.26; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3B; kinase; pp37; Serine/threonine-protein kinase GSK3B; unnamed protein product

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Gene Aliases: GSK3B

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UniProt ID: (Human) P49841

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Entrez Gene ID: (Human) 2932

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Function(s)
nucleotide binding protease binding p53 binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding beta-catenin binding kinase activity transferase activity protein kinase binding ubiquitin protein ligase binding protein kinase A catalytic subunit binding dynactin binding tau protein binding tau-protein kinase activity NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding scaffold protein binding protein serine kinase activity
Process(es)
G1/S transition of mitotic cell cycle epithelial to mesenchymal transition positive regulation of cell-matrix adhesion cytoplasmic translational initiation heart valve development glycogen metabolic process protein phosphorylation ER overload response mitochondrion organization regulation of mitotic cell cycle nervous system development circadian rhythm insulin receptor signaling pathway negative regulation of signal transduction positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition regulation of neuron projection development Wnt signaling pathway peptidyl-serine phosphorylation viral protein processing hippocampus development establishment of cell polarity maintenance of cell polarity cell differentiation positive regulation of cell migration negative regulation of cell migration regulation of axon extension SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neuron projection development negative regulation of protein complex assembly positive regulation of protein complex assembly positive regulation of protein ubiquitination negative regulation of TOR signaling positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of microtubule-based process response to endoplasmic reticulum stress intracellular signal transduction cellular response to interleukin-3 TORC2 signaling regulation of circadian rhythm negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process protein kinase B signaling positive regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of glycogen biosynthetic process positive regulation of cilium assembly positive regulation of translation positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation regulation of protein export from nucleus positive regulation of protein export from nucleus rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis positive regulation of protein kinase B signaling canonical Wnt signaling pathway excitatory postsynaptic potential regulation of microtubule cytoskeleton organization negative regulation of calcineurin-NFAT signaling cascade superior temporal gyrus development cellular response to retinoic acid negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand presynaptic modulation of chemical synaptic transmission neuron projection organization membraneless organelle assembly regulation of microtubule anchoring at centrosome beta-arrestin-dependent dopamine receptor signaling pathway regulation of cellular response to heat negative regulation of protein localization to nucleus regulation of long-term synaptic potentiation positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway cellular response to oxygen-containing compound negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to cilium negative regulation of TORC2 signaling negative regulation of dopaminergic neuron differentiation cellular response to beta-amyloid positive regulation of protein localization to centrosome positive regulation of establishment of protein localization negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of type B pancreatic cell development negative regulation of glycogen (starch) synthase activity negative regulation of mesenchymal stem cell differentiation
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