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Invitrogen
CLAC-P Polyclonal Antibody
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产品信息
PA1-4307
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: K(155) G E Q G D Q G P R M V F P K(169)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-4307 detects CLAC-P (NC2-2 region) in human samples.
PA1-4307 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of 50, 70, and 100 kDa representing CLAC-P in formic acid extracts of Alzheimer's disease brain.
PA1-4307 immunizing peptide corresponds to amino acid residues 155-169 of the NC2-2 region of human and mouse CLAC-P.
靶标信息
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alzheimer disease amyloid-associated protein; AMY; CLAC-P; Collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
基因别名: AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1
UniProt ID: (Human) Q9BXS0
Entrez Gene ID: (Human) 84570
