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Invitrogen
CLEC12A Polyclonal Antibody
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CLEC12A Antibody (PA5-120980) in WB
Western blot analysis of CLEC12A in extracts of K-562 cells. Samples were incubated with CLEC12A Polyclonal antibody (Product # PA5-120980) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
产品信息
PA5-120980
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4).
偶联物
形式
Liquid
浓度
0.72 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: K-562. The target is usually found in the following locations: Cell membrane, Single-pass type II membrane protein.
Immunogen sequence: VTLKIEMKKM NKLQNISEEL QRNISLQLMS NMNISNKIRN LSTTLQTIAT KLCRELYSKE QEHKCKPCPR RWIWHKDSCY FLSDDVQTWQ ESKMACAAQN ASLLKINNKN ALEFIKSQSR SYDYWLGLSP EEDSTRGMRV DNIINSSAWV IRNAPDLNNM YCGYINRLYV QYYHCTYKKR MICEKMANPV QLGSTYFREA
靶标信息
CD371 is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type lectin domain family 12 member A; C-type lectin domain family 12, member A; C-type lectin protein CLL-1; C-type lectin-like molecule 1; C-type lectin-like molecule-1; CD371; CLL-1; DCAL-2; Dendritic cell-associated lectin 2; hKLRL1; Killer cell C-type lectin-like receptor L1; MICL; mKLRL1; Myeloid inhibitory C-type lectin-like receptor
基因别名: CD371; CLEC12A; CLL-1; CLL1; D230024O04; DCAL-2; DCAL2; KLRL1; MICL
UniProt ID: (Human) Q5QGZ9, (Mouse) Q504P2
Entrez Gene ID: (Human) 160364, (Mouse) 232413, (Rat) 680338
