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Invitrogen
CLOCK Recombinant Rabbit Monoclonal Antibody (3D8H6)
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CLOCK Antibody (MA5-38168) in WB
Western blot was performed using Anti-CLOCK Recombinant Rabbit Monoclonal Antibody (ARC1819) (Product # MA5-38168) and a 95 kDa band corresponding to CLOCK was observed across cell lines and tissues tested. Whole cell lysates (30 µg lysate) of U-2 OS (Lane 1), HeLa (Lane 2), A-431 (Lane 3), MCF7 (Lane 4), MCF 10A (Lane 5), and tissue extracts (30 µg lysate) of Mouse Testis (Lane 6), Rat Testis (Lane 7), Mouse Liver (Lane 8), Mouse Skeletal Muscle (Lane 9) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-38168
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3D8H6
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CLOCK (NP_0048891)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HeLa, 293T, NIH/3T3, SH-SY5Y, Mouse lung, Rat brain
Immunogen sequence: WKPTFLSNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR G
靶标信息
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: circadian locomoter output cycles kaput; circadian locomoter output cycles kaput protein; circadian locomotor output cycles kaput; class E basic helix-loop-helix protein 8; clock homolog; KIAA0334; rCLOCK; transcription factor; unnamed protein product
基因别名: 5330400M04Rik; bHLHe8; KAT13D
UniProt ID: (Human) O15516, (Rat) Q9WVS9, (Mouse) O08785
Entrez Gene ID: (Human) 9575, (Rat) 60447, (Mouse) 12753
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
protein binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
peptide-lysine-N-acetyltransferase activity
E-box binding
sequence-specific double-stranded DNA binding
DNA damage checkpoint
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein acetylation
spermatogenesis
female pregnancy
circadian rhythm
response to light stimulus
entrainment of circadian clock
gene expression
regulation of gene expression
circadian regulation of gene expression
regulation of hair cycle
regulation of circadian rhythm
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
regulation of insulin secretion
response to redox state
cellular response to ionizing radiation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
signal transduction
photoperiodism
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