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Invitrogen
CNDP2 Polyclonal Antibody
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CNDP2 Antibody (PA5-87856) in WB
Western blot analysis of CNDP2 in extracts of various cell lines. Samples were incubated with CNDP2 Polyclonal antibody (Product # PA5-87856) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-87856
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CNDP2 (NP_0607052)
偶联物
形式
Liquid
浓度
2.64 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE LVDIGKQKLP DGSEIPLPPI LLGRLGSDPQ KKTVCIYGHL DVQPAALEDG WDSEPFTLVE RDGKLYGRGS TDDKGPVAGW INALEAYQKT GQEIPVNVRF CLEGMEESGS EGLDELIFAR KDTFFKDVDY VCISDNYWLG KKKPCITYGL; Positive Samples: H460, LO2, Mouse kidney, Mouse liver, Mouse lung, Rat lung; Cellular Location: Cytoplasm
靶标信息
The CNDP2 gene encodes the protein carnosine dipeptidase 2, which belongs to the M20 metallopeptidase family and plays a critical role in the metabolism of dipeptides. CNDP2 is primarily involved in the hydrolysis of carnosine, a dipeptide composed of beta-alanine and histidine, and is expressed in various tissues, including the liver and kidney. This enzyme is significant in cellular processes related to nitrogen metabolism and the regulation of histidine-containing dipeptides, which have antioxidant properties influencing cellular redox balance. CNDP2 has implications in renal function and disease, where altered activity can impact the concentration of bioactive peptides involved in protective mechanisms against oxidative stress. Additionally, CNDP2 may have roles in metabolic diseases, such as diabetes and hypertension, where dipeptide regulation can influence metabolic pathways and cellular protection mechanisms. Ongoing research explores CNDP2's enzymatic activity, regulation, and potential therapeutic applications, particularly in conditions where modulation of peptide metabolism can offer clinical benefits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carnosine dipeptidase II; CNDP dipeptidase 2; Cytosolic non-specific dipeptidase; cytosolic nonspecific dipeptidase; cytosolic nonspecific dipeptidase 2; epididymis secretory protein Li 13; Glutamate carboxypeptidase-like protein 1; peptidase 1; Peptidase A; Threonyl dipeptidase
基因别名: 0610010E05Rik; C76600; CN2; CNDP2; CPGL; Dip-2; HEL-S-13; HsT2298; Pep-1; Pep1; PEPA
UniProt ID: (Human) Q96KP4, (Rat) Q6Q0N1, (Mouse) Q9D1A2
Entrez Gene ID: (Human) 55748, (Rat) 291394, (Mouse) 66054
