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Invitrogen
CNF1 Monoclonal Antibody (NG8)
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产品信息
MA1-40275
产品规格
种属反应
Bacteria
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
NG8
抗原
C-terminus of CNF1.
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-40275 detects CNF1 from E. coli samples.
MA1-40275 has been successfully used in ELISA, functional assays and Western blot applications.
The MA1-40275 immunogen is the C-terminus of CNF1.
Endotoxin <24 EU/mg.
靶标信息
Cytotoxic necrotizing factor type 1 and 2 (CNF1 & CNF2) belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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