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Alomone Labs, LTD
CNIH2/3 (extracellular) Polyclonal Antibody
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CNIH2/3 (extracellular) Antibody (AGC-047-200UL) in WB
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4)brain lysates: - 1,2. Anti-CNIH2/3 (extracellular) Antibody (#AGC-047), (1:200).3,4. Anti-CNIH2/3 (extracellular) Antibody , preincubated with CNIH2/3 (extracellular) Blocking Peptide (#BLP-GC047).
产品信息
AGC-047-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RARERLKNIERIC, corresponding to amino acid residues 49-61 of rat CNIH2, Extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Cornichon homologs (CNIHs) are a family of AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Cornichon 2 and 3 (CNIH2/3) are responsible for controlling the export of AMPARs from the endoplasmic reticulum and associate with synaptic AMPARs to modulate channel kinetics. CNIHs are small proteins with three transmembrane domains that directly binds to AMPARs. Overexpression CNIHs and AMPA receptors causes their localization to the Golgi apparatus. CNIH and TARP both compete for the binding to AMPAR subunits GluA2, GluA3, and GluA4 subunits, suggesting both proteins bind to the same site. CNIH2/3 binding to AMPARs is dependent on AMPAR subunit composition and TARPs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CNIH-2; CNIH-3; cornichon 3; Cornichon family AMPA receptor auxiliary protein 2; Cornichon family AMPA receptor auxiliary protein 3; cornichon homolog 2; cornichon homolog 3; Cornichon-like protein; Protein cornichon homolog 2; Protein cornichon homolog 3
基因别名: 2900075G08Rik; CNIH-2; CNIH-3; Cnih2; Cnih3; Cnil; RGD1304930
UniProt ID: (Rat) Q5BJU5, (Mouse) O35089, (Rat) D0Q0Y7, (Mouse) Q6ZWS4
Entrez Gene ID: (Rat) 361705, (Mouse) 12794, (Rat) 690252, (Mouse) 72978
