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Invitrogen
CNOT6 Polyclonal Antibody
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产品信息
PA5-100444
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CNOT6(Accession Q9ULM6), corresponding to amino acid residues Y495-L545.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CNOT6.
靶标信息
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; Cytoplasmic deadenylase
基因别名: CCR4; Ccr4a; Cnot6; Kiaa1194; RGD1310783
UniProt ID: (Mouse) Q8K3P5
Entrez Gene ID: (Human) 57472, (Rat) 287249, (Mouse) 104625
nuclear-transcribed mRNA poly(A) tail shortening
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
gene silencing by miRNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear-transcribed mRNA catabolic process, no-go decay
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
regulation of translation
gene silencing by RNA
