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Invitrogen
CNTF Polyclonal Antibody
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产品信息
PA5-120667
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 24-74 of human CNTF (NP_000605.1).
偶联物
形式
Liquid
浓度
0.64 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: Mouse skeletal muscle. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: ARKIRSDLTA LTESYVKHQG LNKNINLDSA DGMPVASTDQ WSELTEAERL Q
靶标信息
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ciliary neurotrophic factor; ciliary neurotropic factor; CNTF; H-CNTF
基因别名: AI429687; CNTF; HCNTF
UniProt ID: (Human) P26441, (Mouse) P51642, (Rat) P20294
Entrez Gene ID: (Human) 1270, (Mouse) 12803, (Rat) 25707
signal transduction
positive regulation of cell proliferation
positive regulation of gene expression
growth
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of neuron apoptotic process
negative regulation of photoreceptor cell differentiation
regulation of retinal cell programmed cell death
astrocyte activation
muscle organ morphogenesis
neuron development
positive regulation of axon regeneration
ciliary neurotrophic factor-mediated signaling pathway
JAK-STAT cascade
multicellular organism development
nervous system development
positive regulation of phosphatidylinositol 3-kinase signaling
cell differentiation
positive regulation of cell growth
positive regulation of MAPK cascade
positive regulation of JAK-STAT cascade
positive regulation of hormone secretion
protein heterooligomerization
regulation of resting membrane potential
membrane hyperpolarization
negative regulation of neuron death
response to light intensity
response to electrical stimulus
