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Positive Control: mouse brain, rat brain
Predicted Reactivity: Rhesus Monkey (83%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Caspr; caspr1; contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP1; neurexin 4; neurexin 4 (contactin associated protein); Neurexin IV; Neurexin-4; p190; Paranodin
基因别名: AI841080; Caspr; Cntnap1; NCP1; Nrxn4; p190; shm
UniProt ID: (Rat) P97846, (Mouse) O54991
Entrez Gene ID: (Rat) 84008, (Mouse) 53321