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Invitrogen
CNTO 607 Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-59169
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term CNTO 607.
靶标信息
IL13 (Interleukin-13) is a gene located on chromosome 5q31, encoding the IL-13 cytokine, which plays a pivotal role in the immune system, particularly in the regulation of inflammatory and immune responses. IL-13 is predominantly secreted by Th2 cells and is involved in the pathogenesis of allergic reactions and chronic inflammatory conditions such as asthma and ulcerative colitis. This cytokine exerts its effects by binding to the IL-13 receptor complex, which includes IL-13R aplha 1 and IL-4R alpha. Upon binding, IL-13 activates several signaling pathways, including the JAK-STAT pathway, leading to the transcription of genes involved in the immune response. IL-13 is also implicated in tissue remodeling and fibrosis due to its ability to stimulate fibroblast proliferation and collagen production. Dysregulation of IL-13 expression or signaling is associated with various diseases, making it a target for therapeutic intervention, particularly in allergic and autoimmune conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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