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CNX1/2/Calnexin homolog 1/2 Polyclonal Antibody
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CNX1/2/Calnexin homolog 1/2 Antibody (AS12-2365) in WB
Total protein from Col-0 (wild-type) Arabidopsis thaliana were extracted with 50 m M HEPES-KOH buffer containing 250 m M sucrose, 5% glycerol, 50 m M Na PP, 1 m M Na Mo, 25 m M Na F, 10 m M EDTA, 0.5% PVP, 3 m M DTT, 1 m M PMSF, 10 u M Leupeptin & 10 n M Calyculin, and then fractionated by ultracentrifugation at 100,000 x gravity for 30 min at 4°C into soluble (S 100) and microsomal (P 100) proteins as desc... View More
产品信息
AS12-2365
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana CNX1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Nicotiana tabacum, Petunia hybrida, Solanum lycopersicum.
靶标信息
CNX1/2 encode calnexin-family lectin chaperones that localize predominantly to the endoplasmic reticulum membrane, with the bulk of the protein exposed to the ER lumen where nascent secretory and membrane glycoproteins fold. Calnexin proteins are type I single-pass membrane proteins with an N-terminal signal peptide followed by a large luminal lectin/chaperone region (including a globular domain and an extended proline-rich "arm" domain), a C-terminal transmembrane helix, and a short cytosolic tail that can be post-translationally modified to modulate interactions and trafficking. Functionally, CNX1/2 act in the calnexin cycle: they bind monoglucosylated N-linked glycans (e.g., Glc1Man9GlcNAc2) on newly synthesized glycoproteins, thereby promoting productive folding and assembly, limiting aggregation, and retaining incompletely folded clients for additional folding attempts or downstream quality-control disposal; through associated cofactors (notably ER oxidoreductases) they help coordinate disulfide bond formation and broader proteostasis in the early secretory pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT5G07340; AT5G61790; ATCNX1; MAC9.15; MAC9_15; T2I1.50; T2I1_50
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