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Invitrogen
COG2 Polyclonal Antibody
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COG2 Antibody (PA5-76872) in IHC (P)
Immunohistochemistry analysis of COG2 in paraffin-embedded mouse kidney. Samples were incubated with COG2 polyclonal antibody (Product # PA5-76872) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76872
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human COG2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brefeldin A-sensitive, peripheral Golgi protein; COG 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; conserved oligomeric Golgi complex protein 2; Conserved oligomeric Golgi complex subunit 2; low density lipoprotein receptor defect C complementing; Low density lipoprotein receptor defect C-complementing protein; Transcript ch4822
基因别名: 1190002B08Rik; 2700012E02Rik; C86089; COG2; LDLC
UniProt ID: (Human) Q14746, (Mouse) Q921L5
Entrez Gene ID: (Human) 22796, (Mouse) 76332, (Rat) 690961
