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Invitrogen
COL1A2 Polyclonal Antibody
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Product Details
PA5-50938
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the N-terminal region of human COL1A2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
COL1A2 Polyclonal Antibody detects endogenous levels of COL1A2 protein.
Target Information
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; Alpha-2 type I collagen; COL1; collagen 1 pro-alpha-2 chain; Collagen alpha-2(I) chain; collagen COL1A2; Collagen I; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen, type I, alpha 2; epididymis secretory sperm binding protein; osteogenesis imperfecta; pre-pro-alpha-2 type I collagen; procollagen, type I, alpha 2; type I procollagen; unnamed protein product
Gene Aliases: AA960264; AI325291; Col1a-2; COL1A2; Cola-2; Cola2; EDSARTH2; EDSCV; OI4; oim
UniProt ID: (Human) P08123, (Mouse) Q01149, (Rat) P02466
Entrez Gene ID: (Human) 1278, (Mouse) 12843, (Rat) 84352
protease binding
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
protein binding, bridging
identical protein binding
SMAD binding
metal ion binding
platelet-derived growth factor binding
molecular_function
extracellular matrix structural protein
skeletal system development
blood vessel development
transforming growth factor beta receptor signaling pathway
Rho protein signal transduction
regulation of blood pressure
collagen fibril organization
bone mineralization
collagen metabolic process
odontogenesis
skin morphogenesis
animal organ development
protein heterotrimerization
cellular response to amino acid stimulus
extracellular matrix assembly
cellular response to retinoic acid
cellular response to organic substance
response to norepinephrine
cellular response to thyroid hormone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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