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Invitrogen
COL22A1 Polyclonal Antibody
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COL22A1 Antibody (PA5-70816) in WB
Annals of translational medicine 2022 -
Figure 6 HFRL and miR-149-5p synergistically regulated cardiac inflammation, oxidative damage, proliferation, and fibrosis. (A-G) The qRT-PCR, CCK-8, ROS, and western blot assays showed that the knockdown of HFRL by shRNA attenuated HL-1 cardiac function and pro-inflammatory related gene expression, enhanced HL-1 cell proliferation and viability, decreased ROS production, and prohibited pro-fibrotic genes a... View More
产品信息
PA5-70816
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the N-terminal region of human COL22A1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This target displays homology in the following species: Cow: 92%; Dog: 79%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
靶标信息
This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Collagen alpha-1(XXII) chain; collagen, type XXII, alpha 1
基因别名: COL22A1
UniProt ID: (Human) Q8NFW1
Entrez Gene ID: (Human) 169044
