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Invitrogen
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This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 85%; Pig: 86%; Rabbit: 86%; Rat: 85%; Sheep: 85%; Zebrafish: 85%
This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Collagen alpha-1(XXVII) chain; collagen, type XXVII, alpha 1
基因别名: COL27A1; KIAA1870; STLS
UniProt ID: (Human) Q8IZC6
Entrez Gene ID: (Human) 85301