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Invitrogen
COMT Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-32711
Product Specifications
Species Reactivity
Bat,
Bovine,
Human,
Mouse,
Non-human primate,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from internal region of human COMT.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Bovine, Pig (100%) Hamster, Elephant, Panda, Rabbit, Horse (93%).
Target Information
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Catechol O-methyltransferase; catechol-O-methyltransferase 1; catecholamine-O-methyltransferase; OTTHUMP00000197749; OTTHUMP00000197750
Gene Aliases: COMT; Comt1; D16Wsu103e; D330014B15Rik
UniProt ID: (Bovine) A7MBI7, (Mouse) O88587, (Rat) P22734
Entrez Gene ID: (Pig) 100155530, (Bovine) 618278, (Mouse) 12846, (Rat) 24267
methylation
neurotransmitter catabolic process
catecholamine catabolic process
catecholamine metabolic process
female pregnancy
learning
short-term memory
estrogen metabolic process
catechol-containing compound metabolic process
cellular response to phosphate starvation
negative regulation of renal sodium excretion
dopamine metabolic process
dopamine catabolic process
negative regulation of dopamine metabolic process
response to pain
multicellular organismal reproductive process
negative regulation of smooth muscle cell proliferation
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
response to organic cyclic compound
response to lipopolysaccharide
developmental process
response to drug
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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