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Invitrogen
CORIN Polyclonal Antibody
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CORIN Antibody (PA5-87872) in WB
Western blot analysis of CORIN in extracts of various cell lines. Samples were incubated with CORIN Polyclonal antibody (Product # PA5-87872) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-87872
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragments)
偶联物
形式
Liquid
浓度
0.99 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV LIPCICALVL LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN TIYNQSTVVS; Positive Samples: Hela, HT-1080, Mouse heart, Mouse brain, Rat heart, Rat brain; Cellular Location: Cell membrane, Single-pass type II membrane protein, Single-pass type II membrane protein
靶标信息
CORIN is a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. CORIN converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atrial natriuretic peptide-converting enzyme; Corin; EC 3.4.21; Heart-specific serine proteinase ATC2; Low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; MGC119742; pro-ANP-convertase; Pro-ANP-converting enzyme; PRSC; serine peptidase; serine protease; Transmembrane protease serine 10
基因别名: ATC2; AV273130; CORIN; CRN; Lrp4; PEE5; TMPRSS10
UniProt ID: (Human) Q9Y5Q5, (Mouse) Q9Z319, (Rat) Q80YN4
Entrez Gene ID: (Human) 10699, (Mouse) 53419, (Rat) 289596
regulation of systemic arterial blood pressure by atrial natriuretic peptide
female pregnancy
regulation of blood pressure
peptide hormone processing
regulation of renal sodium excretion
regulation of cardiac conduction
proteolysis
protein processing
neuron differentiation
receptor-mediated endocytosis
