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Invitrogen
COX7A2/COX7A3 Polyclonal Antibody
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COX7A2/COX7A3 Antibody (PA5-99611) in ICC/IF
Immunofluorescent analysis of COX7A2/COX7A3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and COX7A2/COX7A3 polyclonal antibody (Product # PA5-99611) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fl... View More
产品信息
PA5-99611
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human COX7A2P2(Accession O60397), corresponding to amino acid residues L5-H55.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total COX7a2/3.
靶标信息
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. COX7A2 is predicted to enable electron transfer activity, to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation, and to be part of mitochondrial respiratory chain complex IV.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytochrome c oxidase polypeptide 7A2, mitochondrial; cytochrome c oxidase polypeptide VIIa-liver/heart; Cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa polypeptide 2 (liver); Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart; cytochrome c oxidase subunit VIIaL; cytochrome c oxidase, subunit 7a 3; cytochrome c oxidase, subunit VIIa 2; hepatic cytochrome-c oxidase chain VIIa
基因别名: COX7A2; Cox7a3; COX7AL; COX7AL1; COXVIIa-L; COXVIIAL; VIIAL
UniProt ID: (Human) P14406, (Rat) P35171, (Mouse) P48771
Entrez Gene ID: (Human) 1347, (Rat) 29507, (Mouse) 12866
