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Invitrogen
CPA6 Polyclonal Antibody
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CPA6 Antibody (PA5-103706) in ICC/IF
Immunocytochemistry analysis of CPA6 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CPA6 polyclonal antibody (Product # PA5-103706) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-103706
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CPA6(Accession Q8N4T0), corresponding to amino acid residues V240-D290.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CPA6.
靶标信息
Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus, which is cleaved off upon enzyme activation. Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus. CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides. Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve). There are three isoforms of CPA6 that exist as a result of alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carboxypeptidase A6; carboxypeptidase B; metallocarboxypeptidase
基因别名: 9030616D13Rik; CPA6; CPAH; ETL5; FEB11
UniProt ID: (Human) Q8N4T0, (Mouse) Q5U901
Entrez Gene ID: (Human) 57094, (Mouse) 329093, (Rat) 312913
