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Invitrogen
CRALBP Polyclonal Antibody
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CRALBP Antibody (PA5-83588) in IHC (P)
Immunohistochemistry analysis of CRALBP in human eye, retina, liver, lymphoid tissues and squamous epithelia. Samples were incubated with CRALBP polyclonal antibody (Product # PA5-83588). Shows similar protein distribution across tissues to independent CRALBP antibody (Product # PA5-83702) (B).
产品信息
PA5-83588
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TTKDHGPVFG PCSQLPRHTL QKAKDELNER EETREEAVRE LQEMVQAQAA SGEELAVAVA ERVQEKDSGF FLRFIRARKF NVGRAYELLR GYVNFRL
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 91%.
靶标信息
Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; Retinaldehyde-binding protein 1
基因别名: CRALBP; RLBP1
UniProt ID: (Human) P12271
Entrez Gene ID: (Human) 6017
