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Invitrogen
CREM Polyclonal Antibody
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产品信息
PA5-29927
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human CREM. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: NT2D1, Neuro2A, GL261, PC-12, Rat2.
Predicted reactivity: Mouse (93%), Rat (91%), Dog (86%), Chicken (88%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cAMP response element modulator; cAMP responsive element moderator; cAMP-responsive element modulator; CRE modulator; CREM 2alpha-b protein; CREM 2beta-a protein; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; inducible cyclic AMP early repressor; MGC111110; MGC17881; MGC41893; OTTHUMP00000019443
基因别名: CREM; CREM-2; hCREM-2; ICER; ICERI
UniProt ID: (Human) Q03060, (Rat) Q03061, (Mouse) P27699
Entrez Gene ID: (Human) 1390, (Rat) 25620, (Mouse) 12916
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
fatty acid metabolic process
glycosphingolipid metabolic process
spermatogenesis
cAMP-mediated signaling
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
response to cAMP
rhythmic process
signal transduction
multicellular organism development
cell differentiation
