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          • Primary Antibodies ›
          • CRK Antibodies

          Invitrogen

          CRK Polyclonal Antibody

          查看其他24个CRK抗体

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          Cite CRK Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (5)
          CRK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          CRK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 5

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          CRK Antibody (PA5-79067) in IHC (P)

          Immunohistochemistry (Paraffin) analysis of CRK in paraffin-embedded section of human lung cancer tissue using CRK Polyclonal Antibody (Product # PA5-79067). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight at 4°... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          CRK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CRK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CRK Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CRK Antibody in Western Blot (WB)
          CRK Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          CRK Polyclonal Antibody

          产品信息

          PA5-79067

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          0.1-0.5 µg/mL
          -

          免疫组化(石蜡) (IHC (P))

          2-5 µg/mL
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          E.coli-derived human Crk p38 recombinant protein (Position: A2-R246).
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Lyophilized

          浓度

          500 µg/mL

          规格

          100 µg

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS with 5mg BSA

          内含物

          0.01mg sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2746183

          产品详细信息

          Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

          Positive Control - WB: human 293T whole cell, human A549 whole cell, rat liver tissue, mouse liver tissue. IHC: human lung cancer tissue, mouse brain tissue, rat brain tissue.

          靶标信息

          The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK-II; Crk3; CSAID-binding protein; Csaids binding protein; CT-10 related kinase 3; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX-interacting protein 2; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; negative regulator of Crk tyrosine-phosphorylation; p38; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; proto-oncogene C-crk; reactive kinase; SAPK2a; CSAIDS binding protein 1; stress-activated protein kinase 2A; unnamed protein product; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_1; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_2; v-crk sarcoma virus CT10 oncogene-like protein

          查看更多 收起

          基因别名: c-Crk; Crk-I; Crk-II; Crk-III; CRK1; Crk3; CRKII; CrkIII; Crko; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Hog; Mxi2; p38; p38-alpha; p38a; p38ALPHA; p38Hog; p38MAPK; PRKM14; PRKM15; RK; SAPK2A

          查看更多 收起

          UniProt ID: (Human) P46108, (Mouse) Q64010, (Rat) Q63768, (Human) Q16539, (Mouse) P47811

          查看更多 收起

          Entrez Gene ID: (Human) 1398, (Mouse) 12928, (Rat) 54245, (Human) 1432, (Mouse) 26416, (Rat) 81649

          查看更多 收起

          功能
          phosphotyrosine binding insulin-like growth factor receptor binding protein binding cytoskeletal protein binding SH3 domain binding enzyme binding kinase binding protein domain specific binding receptor signaling complex scaffold activity protein binding, bridging receptor tyrosine kinase binding ubiquitin protein ligase binding signaling adaptor activity SH2 domain binding protein phosphorylated amino acid binding scaffold protein binding protein tyrosine kinase binding ephrin receptor binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity ATP binding protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein serine kinase activity kinase activity
          参与通路
          MAPK cascade negative regulation of inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway positive regulation of gene expression positive regulation of myotube differentiation platelet activation osteoclast differentiation stress-activated protein kinase signaling cascade positive regulation of cyclase activity positive regulation of interleukin-12 production negative regulation of hippo signaling intracellular signal transduction cellular response to vascular endothelial growth factor stimulus p38MAPK cascade signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation vascular endothelial growth factor receptor signaling pathway positive regulation of muscle cell differentiation stress-activated MAPK cascade 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to ionizing radiation cellular response to UV-B cellular senescence stress-induced premature senescence cellular response to virus regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion positive regulation of reactive oxygen species metabolic process DNA damage checkpoint cell morphogenesis cartilage condensation angiogenesis osteoblast differentiation placenta development response to dietary excess chondrocyte differentiation glucose metabolic process regulation of transcription, DNA-templated protein phosphorylation cellular response to DNA damage stimulus transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development myoblast differentiation involved in skeletal muscle regeneration peptidyl-serine phosphorylation fatty acid oxidation regulation of ossification lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide response to insulin tumor necrosis factor-mediated signaling pathway response to muscle stretch positive regulation of protein import into nucleus positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import protein autophosphorylation striated muscle cell differentiation protein maturation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation bone development pyroptosis cellular response to tumor necrosis factor negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation regulation of synaptic membrane adhesion NLRP1 inflammasome complex assembly neuron migration response to yeast regulation of leukocyte migration lipid metabolic process enzyme linked receptor protein signaling pathway synapse assembly cell proliferation regulation of cell shape regulation of signal transduction positive regulation of smooth muscle cell migration dendrite development cell migration hippocampus development cerebral cortex development establishment of cell polarity actin cytoskeleton organization positive regulation of cell growth regulation of actin cytoskeleton organization regulation of cell adhesion mediated by integrin regulation of Rac protein signal transduction positive regulation of Rac protein signal transduction helper T cell diapedesis response to hepatocyte growth factor reelin-mediated signaling pathway response to hydrogen peroxide negative regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade ephrin receptor signaling pathway regulation of dendrite development cell chemotaxis negative regulation of wound healing response to cholecystokinin cellular response to transforming growth factor beta stimulus cellular response to nitric oxide protein localization to membrane activation of GTPase activity postsynaptic specialization assembly cerebellar neuron development positive regulation of substrate adhesion-dependent cell spreading response to peptide regulation of intracellular signal transduction cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus cellular response to endothelin negative regulation of cell motility regulation of T cell migration cell adhesion regulation of wound healing regulation of cell motility regulation of immune system process regulation of cell migration positive regulation of intracellular signal transduction response to glucose phosphorylation cellular response to acetaldehyde
          It has to be done as per old AB suggested Products section.

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