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CRMP5 Antibody (MA5-42815) in IHC (P)
Immunohistochemistry analysis of CRMP5 in paraffin-embedded human appendix. Samples were incubated with CRMP5 Monoclonal antibody (Product # MA5-42815) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42815
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5L4S8
抗原
A synthetic peptide corresponding to a sequence within amino acids 465-564 of human CRMP5/DPYSL5 (Q9BPU6).
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911956
产品详细信息
Positive test controls include: SH-SY5Y, Mouse testis, Rat testis. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: RSFPDTVYKK LVQREKTLKV RGVDRTPYLG DVAVVVHPGK KEMGTPLADT PTRPVTRHGG MRDLHESSFS LSGSQIDDHV PKRASARILA PPGGRSSGIW
靶标信息
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Collapsin response mediator protein 5; collapsin response mediator protein-5; CRAM; CRMP-5; CRMP3-associated molecule; dihydropyrimidinase-like 5; Dihydropyrimidinase-related protein 5; DRP-5; ULIP-6; ULIP6 protein; UNC33-like phosphoprotein 6
基因别名: CRAM; CRMP-5; CRMP5; DPYSL5; ULIP6
UniProt ID: (Human) Q9BPU6, (Rat) Q9JHU0, (Mouse) Q9EQF6
Entrez Gene ID: (Human) 56896, (Rat) 65208, (Mouse) 65254
