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Invitrogen
CRSP130 Polyclonal Antibody
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CRSP130 Antibody (PA5-87691) in WB
Western blot analysis of CRSP130 in extracts of various cell lines. Samples were incubated with CRSP130 Polyclonal antibody (Product # PA5-87691) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-87691
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 890-1110 of human MED23 (NP_0012574501)
偶联物
形式
Liquid
浓度
3.76 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LLKPNDFRNR VSDFVKENSP EHWLQNDWHT KHMNYHKKYP EKLYFEGLAE QVDPPVQIQS PYLPIYFGNV CLRFLPVFDI VIHRFLELLP VSKSLETLLD HLGGLYKFHD RPVTYLYNTL HYYEMHLRDR AFLKRKLVHA IIGSLKDNRP QGWCLSDTYL KCAMNAREEN PWVPDDTYYC RLIGRLVDTM AGKSPGPFPN CDWRFNEFPN PAAHALHVTC V; Positive Samples: Mouse brain, Rat brain; Cellular Location: Nucleus
靶标信息
CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; Activator-recruited cofactor 130 kDa component; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); CRSP complex subunit 3; DRIP130; hSur-2; Mediator complex subunit 23; mediator complex subunit MED23 variant MED23_i6; mediator complex subunit MED23 variant MED23_i7; Mediator of RNA polymerase II transcription subunit 23; mSur-2; Protein sur-2 homolog; Transcriptional coactivator CRSP130; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component
基因别名: 130kDa; 3000002A17Rik; ARC130; CRSP130; CRSP133; CRSP3; DRIP130; ESTM7; KIAA1216; MED23; mKIAA1216; MRT18; SUR-2; SUR2; X83317
UniProt ID: (Human) Q9ULK4, (Mouse) Q80YQ2
Entrez Gene ID: (Human) 9439, (Rat) 309565, (Mouse) 70208
