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Abnova
CRTAM Polyclonal Antibody, MaxPab™
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Product Details
H00056253-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRTAM (AAH70266.1, 1 a.a. approximately 393 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL NEYPVLKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI LFIIVQLFIM KLRKTHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ SSHPMRCMNY ITKLYSEGKT KRKENVQHSK LEEKHIQVPE SIV
Target Information
Class-I MHC-restricted T cell-associated molecule (CRTAM) is a gene located on chromosome 11q24.2, encoding a member of the immunoglobulin superfamily that plays a crucial role in immune cell interactions. CRTAM is expressed on activated CD8+ T cells, natural killer (NK) cells, and some subsets of CD4+ T cells, where it is involved in promoting cell adhesion, cytokine production, and cytotoxic responses. The protein binds to Necl-2 (CD112), mediating intercellular communication that influences immune responses, particularly in the context of viral infections and tumor surveillance. CRTAM's involvement in directing immune cell activity highlights its importance in the regulation of adaptive and innate immunity. Research into CRTAM is exploring its potential as a therapeutic target for modulating immune functions, aiming to enhance immune responses against cancer and infectious diseases or to attenuate autoimmune reactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD355; CD355 antigen; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule
Gene Aliases: CD355; CRTAM
UniProt ID: (Human) O95727
Entrez Gene ID: (Human) 56253
T cell mediated cytotoxicity
detection of tumor cell
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell recognition
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of cytokine secretion
regulation of immune response
activated T cell proliferation
detection of stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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