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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: LIGLFELPED DTIPDEEHFI DIEDTPGYQT AFSQLAFAGK KEHDPVGQMV NNPKIHLAQS LHKLSTACPG RVPSMVSTSL NAEALQYLQG YLQAARVTLL
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BCR/ABL fusion protein; BCR/ABL1 fusion; CAS; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; CSE1 chromosome segregation 1-like; epididymis secretory sperm binding protein; exp2; importin-alpha re-exporter; MGC117283; MGC130036; MGC130037; putative Ran-binding domain; unnamed protein product
基因别名: CAS; CSE1; XPO2
UniProt ID: (Human) P55060
Entrez Gene ID: (Human) 1434