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Invitrogen
CSN7b Polyclonal Antibody
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产品信息
PA5-113385
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)
偶联物
形式
Liquid
浓度
3 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arabidopsis; COP9 complex S7b; COP9 constitutive photomorphogenic homolog subunit 7B; COP9 signalosome complex subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b
基因别名: COPS7B; CSN7B; D1Wsu66e; E130114M23; SGN7b
UniProt ID: (Human) Q9H9Q2, (Mouse) Q8BV13
Entrez Gene ID: (Human) 64708, (Mouse) 26895
