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Invitrogen
CSN7b Polyclonal Antibody
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产品信息
PA5-57010
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GELLELANVQ ELAEGANAAY LQLLNLFAYG TYPDYIANKE SLPELSTAQQ NKLKHLTIVS LASRMKCIPY SV
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
靶标信息
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arabidopsis; COP9 constitutive photomorphogenic homolog subunit 7B; COP9 signalosome complex subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b
基因别名: COPS7B; CSN7B; SGN7b
UniProt ID: (Human) Q9H9Q2
Entrez Gene ID: (Human) 64708
