Search
Invitrogen
CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 9
CSNK1A1/CSNK1A1L Antibody (MA5-56415) in ICC/IF
Immunocytochemistry analysis of CSNK1A1/CSNK1A1L with HCT 116 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp). Next they were incubated with CSNK1A1/CSNK1A1L Recombinant Monoclonal Antibody (Product # MA5-56415)at a dilution of 1:500 in 1% BSA in PBST over... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56415
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH04-58
抗原
Recombinant protein within human CSNK1A1 aa 1-337/337.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CSNK1A1 (casein kinase 1 alpha 1) and CSNK1A1L (casein kinase 1 alpha 1-like) are serine/threonine protein kinases involved in various cellular processes. CSNK1A1 is located on chromosome 5 (5q32) and functions as a putative tumor suppressor, playing a role in cell cycle regulation, apoptosis, and autophagy. It is involved in the CGAS-STING pathway, inhibiting the overactivation of type I interferon signaling by promoting autophagic degradation of STING1. Additionally, CSNK1A1 has implications in certain cancers and myelodysplastic syndromes where its regulation affects cell proliferation and sensitivity to therapies. In contrast, CSNK1A1L is a paralog of CSNK1A1 that shares similar functional domains and potentially overlapping functions, although its specific role and regulatory mechanisms remain less characterized. Both genes are involved in critical pathways regulating cell survival and immune response, and their dysregulation is associated with disease states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; casein kinase I-alpha; CK1; CKI-alpha; CKI-alpha-like
基因别名: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1a; Csnk1a; CSNK1A1; CSNK1A1L
UniProt ID: (Rat) P97633, (Mouse) Q8BK63
Entrez Gene ID: (Rat) 113927, (Mouse) 93687
magnesium ion binding
glycoprotein binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
peptide binding
phosphoprotein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
