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Abnova
CSNK1A1L Polyclonal Antibody, MaxPab™
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产品信息
H00122011-B03P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CSNK1A1L (NP_660204.1, 1 a.a. approximately 337 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EEVAVKLESQ KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR RDDMESLGYV FMYFNRTSLP WQGLKAMTKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN
靶标信息
CSNK1A1L serine/threonine kinase or CK1-alpha dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. It governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. These kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins including CTNNB1, PER1, and PER2. CSNK1A1 also participates in Wnt signaling. It may play a role in segregating chromosomes during mitosis, as well as, cytoskeleton diassembly which may regulate epithelial cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha-like; CK1; CKI-alpha-like
基因别名: CK1; CSNK1A1L
UniProt ID: (Human) Q8N752
Entrez Gene ID: (Human) 122011
