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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: AIITQVTNPK EDEGRLPGAG EKASQCNVSL KKQRSRSILS SFFCCFRDYN VEAPPPSSPS VLPPLVEENG GLQKGDQ
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 41%.
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD small phosphatase-like protein; CTDSP-like; hYA22; MGC71888; NIF-like protein; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; Protein YA22; RBSP3; SCP-3; SCP3; SCP3 COR1; Small C-terminal domain phosphatase 3
Gene Aliases: C3orf8; CTDSPL; NIF1; NIFL; SCP3; YA22
Entrez Gene ID: (Human) 10217
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