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Invitrogen
CTGF Polyclonal Antibody
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FIGURE: 1 / 6
CTGF Antibody (PA1-16634) in ICC/IF
Immunofluorescence analysis of CTGF was performed using 70% confluent log phase HUVEC cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with CTGF Polyclonal Antibody (Product # PA1-16634) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), (1:20... View More
Product Details
PA1-16634
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a C-terminal portion of human CTGF (between residues 299-349).
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with porcine, bovine, chicken and sheep based on 100% sequence homology.
Suggested positive control: mouse kidney lysate or protein.
Target Information
Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); Connective tissue growth-related protein; fibroblast inducible secreated protein; fibroblast inducible secreted protein; H-CTGF; hypertrophic chondrocyte-specific gene product 24; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839; Protein FISP-12
Gene Aliases: betaIG-M2; CCN2; CTGF; CTGRP; Fisp-12; Fisp12; HCS24; IGFBP8; NOV2
UniProt ID: (Human) P29279, (Mouse) P29268, (Rat) Q9R1E9
Entrez Gene ID: (Human) 1490, (Mouse) 14219, (Rat) 64032
cartilage condensation
ossification
angiogenesis
regulation of cell growth
tissue homeostasis
transcription initiation from RNA polymerase II promoter
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
epidermis development
response to wounding
response to glucose
organ senescence
positive regulation of gene expression
negative regulation of gene expression
cell migration
cell differentiation
lung development
regulation of chondrocyte differentiation
response to estradiol
positive regulation of collagen biosynthetic process
response to anoxia
intracellular signal transduction
chondrocyte proliferation
response to amino acid
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to peptide hormone
positive regulation of cell differentiation
positive regulation of JNK cascade
positive regulation of cell activation
response to mineralocorticoid
positive regulation of stress fiber assembly
cytosolic calcium ion transport
positive regulation of cardiac muscle contraction
negative regulation of cell death
extracellular matrix constituent secretion
positive regulation of G0 to G1 transition
positive regulation of ERK1 and ERK2 cascade
response to fatty acid
DNA biosynthetic process
reactive oxygen species metabolic process
positive regulation of protein phosphorylation
positive regulation of cell death
connective tissue development
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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