Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Enterprise Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • Promotions
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Order Status
          • Quick Order
          • Promos
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Aspire Member Program
            • Connect: Lab, Data, Apps
            • Custom Products & Projects
            • Services Central

          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • beta Catenin Antibodies

          Abnova

          CTNNB1 Monoclonal Antibody (4H4)

          查看其他126个beta Catenin抗体

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite CTNNB1 Monoclonal Antibody (4H4)

          • 抗体检测数据 (3)
          CTNNB1 Antibody in ELISA (ELISA)
          Group 53 Created with Sketch.
          CTNNB1 Antibody in ELISA (ELISA)
          Group 53 Created with Sketch.

          图: 1 / 3

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          CTNNB1 Antibody (H00001499-M05) in ELISA

          Detection limit for recombinant GST tagged CTNNB1 is 0.1 ng/mL as a capture antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          CTNNB1 Antibody in Immunocytochemistry (ICC/IF)
          CTNNB1 Antibody in Western Blot (WB)
          CTNNB1 Antibody in ELISA (ELISA)
          CTNNB1 Monoclonal Antibody (4H4)

          产品信息

          H00001499-M05

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-5 µg/mL
          -

          免疫细胞化学 (ICC/IF)

          10 µg/mL
          -

          酶联免疫吸附实验 (ELISA)

          0.1 ng/mL
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Mouse / IgG2a, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          4H4

          抗原

          CTNNB1 (AAH58926, 682 a.a. approximately 781 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          See Label

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.4

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Sequence of this protein is as follows: LFRTEPMAWN ETADLGLDIG AQGEPLGYRQ DDPSYRSFHS GGYGQDALGM DPMMEHEMGG HHPGADYPVD GLPDLGHAQD LMDGLPPGDS NQLAWFDTDL

          靶标信息

          Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

          您是否在文献中引用过该产品?请点击下方按钮邮件告知我们。
          引用该产品

          生物信息学

          蛋白别名: Bcatenin; beta 1 88kDa; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; β catenin; βcatenin

          查看更多 收起

          基因别名: armadillo; CTNNB; CTNNB1; MRD19; OK/SW-cl.35; PRO2286

          查看更多 收起

          UniProt ID: (Human) P35222

          查看更多 收起

          Entrez Gene ID: (Human) 1499

          查看更多 收起

          功能
          RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity signal transducer activity protein binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding protein phosphatase binding estrogen receptor binding protein complex binding ionotropic glutamate receptor binding nuclear hormone receptor binding transcription regulatory region DNA binding ion channel binding alpha-catenin binding cadherin binding SMAD binding androgen receptor binding nitric-oxide synthase binding I-SMAD binding repressing transcription factor binding cadherin binding involved in cell-cell adhesion euchromatin binding
          参与通路
          negative regulation of transcription from RNA polymerase II promoter embryonic axis specification patterning of blood vessels branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second cell fate specification endodermal cell fate commitment neuron migration epithelial to mesenchymal transition neural plate development liver development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated cell adhesion cell-matrix adhesion Wnt signaling pathway, calcium modulating pathway chemical synaptic transmission ectoderm development glial cell fate determination midgut development negative regulation of cell proliferation anterior/posterior axis specification dorsal/ventral axis specification proximal/distal pattern formation positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Schwann cell proliferation response to activity Wnt signaling pathway single organismal cell-cell adhesion stem cell population maintenance layer formation in cerebral cortex central nervous system vasculogenesis osteoclast differentiation androgen receptor signaling pathway male genitalia development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol positive regulation of type I interferon production T cell differentiation in thymus negative regulation of protein sumoylation response to cytokine adherens junction assembly protein localization to cell surface embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hair cell differentiation catenin import into nucleus embryonic skeletal limb joint morphogenesis regulation of T cell proliferation odontogenesis of dentin-containing tooth response to drug embryonic digit morphogenesis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of neuron apoptotic process response to estrogen canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition canonical Wnt signaling pathway involved in negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus myoblast differentiation bone resorption positive regulation of endothelial cell differentiation positive regulation of osteoblast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic response to cadmium ion chromatin-mediated maintenance of transcription regulation of fibroblast proliferation cell maturation synaptic vesicle transport thymus development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis negative regulation of oligodendrocyte differentiation regulation of neurogenesis synapse organization positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization positive regulation of histone H3-K4 methylation positive regulation of telomerase activity oviduct development canonical Wnt signaling pathway trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development cranial ganglion development regulation of centromeric sister chromatid cohesion cellular response to mechanical stimulus cellular response to lithium ion cellular response to growth factor stimulus cellular response to indole-3-methanol renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import negative regulation of neuron death positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding regulation of core promoter binding beta-catenin-TCF complex assembly beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation cellular response to insulin-like growth factor stimulus embryonic brain development dorsal root ganglion development regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of DNA-templated transcription, initiation negative regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.
          guarantee_icon

          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

          了解更多
          help_icon

          随时为您服务

          获取常见问题的专家解答,或者直接联系我们的技术专家,咨询应用、设备、常规产品使用问题。

          联系技术支持
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Consumer Health Data Privacy Policy Consumer Health Data Privacy Policy
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Information Center
          • Price & Freight Policy
          © 2006-2025 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          United States flag icon
          United States

          Your items have has been added!


          Host server : magellan-search-green-55658555d6-g8zmf:80/100.66.76.99:80.
          git-commit: ec8e7df5f8fec8d765bd419205f1b5046a016d37
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.41.0-Offline