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Invitrogen
CTR1 Polyclonal Antibody
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CTR1 Antibody (PA5-80029) in WB
Western blot analysis of CTR1 in Lane 1: human HepG2 whole cell lysate, Lane 2: human PANC-1 whole cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CTR1 polyclonal antibody (Product # PA5-80029) at a dilution of 0.5 µg/mL (overnight at 4°C), followe... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80029
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human SLC31A1/CTR1 (NGTILMETHKTVGQQMLSFPHLLQTVLHIIQ).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human PANC-1 whole cell.
靶标信息
The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: At5g03730; AtCTR1; CONSTITUTIVE TRIPLE RESPONSE 1; copper transport 1 homolog; copper transporter 1; Copper uptake transporter 1; CTR1; F17C15.150; F17C15_150; liver regeneration-related protein LRRGT00200; rCTR1; SIS1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1; SUGAR-INSENSITIVE 1; unnamed protein product
基因别名: 4930445G01Rik; COPT1; CTR1; LRRGT00200; NSCT
UniProt ID: (Human) O15431, (Mouse) Q8K211, (Rat) Q9JK41
Entrez Gene ID: (Human) 1317, (Mouse) 20529, (Rat) 171135
angiogenesis
copper ion transport
copper ion import
plasma membrane copper ion transport
metal ion transport
copper ion transmembrane transport
vascular endothelial growth factor receptor-2 signaling pathway
xenobiotic transport
protein oligomerization
silver ion transmembrane transport
cellular copper ion homeostasis
transmembrane transport
cellular response to cisplatin
copper ion import across plasma membrane
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
