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Invitrogen
CTR1 Polyclonal Antibody
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CTR1 Antibody (PA5-87637) in WB
Western blot analysis of CTR1 in extracts of various cell lines. Samples were incubated with CTR1 Polyclonal antibody (Product # PA5-87637) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-87637
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SLC31A1 (NP_0018501)
偶联物
形式
Liquid
浓度
0.98 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG; Positive Samples: A-549, NCI-H460, Mouse liver, Mouse kidney; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: copper transport 1 homolog; Copper transporter 1; CTR1; hCTR1; High affinity copper uptake protein 1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1; Solute carrier family 31 member 1
基因别名: 4930445G01Rik; AI787263; AU016967; COPT1; CTR1; SLC31A1
UniProt ID: (Human) O15431, (Mouse) Q8K211
Entrez Gene ID: (Human) 1317, (Mouse) 20529
