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Invitrogen
CTRP3 Polyclonal Antibody
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产品信息
PA5-148594
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse CTRP3/C1qTNF3/CORS26, Gln23-Lys246, predicted
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Multiple isoforms of human CTRP3 have been reported. It has been suggested that CTRP3 may play a role in skeletal development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cartducin; cartonectin; Collagenous repeat-containing sequence 26 kDa protein; Complement C1q tumor necrosis factor-related protein 3; CORS26; Secretory protein CORS26
基因别名: 2310005P21Rik; C1qtnf3; Corcs; Cors; CORS-26; CORS26; CTRP3
UniProt ID: (Mouse) Q9ES30
Entrez Gene ID: (Mouse) 81799
negative regulation of gene expression
cellular triglyceride homeostasis
negative regulation of NF-kappaB import into nucleus
glucose homeostasis
negative regulation of gluconeogenesis
positive regulation of cytokine secretion
negative regulation of inflammatory response
protein oligomerization
positive regulation of protein kinase B signaling
positive regulation of adiponectin secretion
protein trimerization
positive regulation of ERK1 and ERK2 cascade
negative regulation of monocyte chemotactic protein-1 production
negative regulation of interleukin-6 secretion
