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Invitrogen
CUG-BP Polyclonal Antibody
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Product Details
PA5-36277
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 62-115 of human CUG-BP1/2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 50 and 54 kDa.
Purity is >95% by SDS-PAGE.
Target Information
CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 50 kDa nuclear polyadenylated RNA-binding protein; Brain protein F41; bruno-like 2; Bruno-like protein 2; Bruno-like protein 3; CELF-1; CELF-2; CUG RNA-binding protein; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 1; CUG-BP- and ETR-3-like factor 2; CUG-BP1; CUG-BP2; CUGBP Elav-like family member 1; CUGBP Elav-like family member 2; Cugbp- and Etr3-like factor 2; Deadenylation factor CUG-BP; Deadenylation factor EDEN-BP; EDEN-BP homolog; ELAV-type RNA-binding protein 3; embryo deadenylation element binding protein; Embryo deadenylation element-binding protein homolog; ETR-3; hNAPOR; KDM2B/CELF2 fusion; mNapor; NAPOR-4; Neuroblastoma apoptosis-related RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; RNA-binding protein; RNA-binding protein BRUNOL-2; RNA-binding protein BRUNOL-3; RNA-binding protein Brunol3; rNapor; unnamed protein product
Gene Aliases: 1600010O03Rik; AA407467; B230218O03; B230345P09Rik; BRUNOL2; BRUNOL3; C88023; CELF-2; CELF1; CELF2; CUG-BP; CUG-BP1; CUG-BP2; CUGBP; CUGBP1; CUGBP2; D230046B21Rik; D2Wsu101e; DEE97; EDEN-BP; ETR-3; ETR3; HNAB50; mETR-3; NAB50; NAPOR; Napor-2
UniProt ID: (Human) Q92879, (Human) O95319, (Mouse) P28659, (Rat) Q4QQT3, (Rat) Q792H5, (Mouse) Q9Z0H4
Entrez Gene ID: (Human) 10658, (Human) 10659, (Mouse) 13046, (Rat) 362160, (Rat) 29428, (Mouse) 14007
mRNA splice site selection
mRNA processing
regulation of alternative mRNA splicing, via spliceosome
germ cell development
negative regulation of cell proliferation
RNA splicing
embryo development ending in birth or egg hatching
positive regulation of gene expression
negative regulation of gene expression
posttranscriptional gene silencing
negative regulation of translation
posttranscriptional gene silencing by RNA
regulation of RNA splicing
regulation of inflammatory response
mRNA destabilization
spermatid development
positive regulation of multicellular organism growth
RNA processing
regulation of heart contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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