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CX3CL1 Polyclonal Antibody

查看其他23个CX3CL1抗体

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CX3CL1 Polyclonal Antibody

产品信息

PA5-20296

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.5-2 µg/mL
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11153478

产品详细信息

Despite the predicted molecular weight, CX3CL1 often migrates at 80-100kDa in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is C2C12 cell lysate.

PA5-20296 can be used with blocking peptide PEP-0398.

靶标信息

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ABCD-3; C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1; unnamed protein product

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基因别名: A-152E5.2; AB030188; ABCD-3; AI848747; C3Xkine; CX3C; CX3CL1; CXC3; CXC3C; D8Bwg0439e; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1

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UniProt ID: (Human) P78423, (Mouse) O35188

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Entrez Gene ID: (Human) 6376, (Mouse) 20312

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功能
receptor binding cytokine activity integrin binding protein binding chemokine activity CX3C chemokine receptor binding chemoattractant activity CXCR1 chemokine receptor binding CCR chemokine receptor binding cytokine intercellular signal molecule
参与通路
microglial cell activation positive regulation of cell-matrix adhesion positive regulation of neuroblast proliferation leukocyte migration involved in inflammatory response response to ischemia chemotaxis defense response inflammatory response immune response cell adhesion G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation negative regulation of cell-substrate adhesion positive regulation of neuron projection development neuron remodeling cytokine-mediated signaling pathway positive regulation of cell migration negative regulation of cell migration neutrophil chemotaxis leukocyte chemotaxis regulation of lipopolysaccharide-mediated signaling pathway positive regulation of actin filament bundle assembly negative regulation of interleukin-1 alpha production negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of transforming growth factor beta1 production integrin activation autocrine signaling wound healing negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of neurogenesis leukocyte adhesive activation positive chemotaxis positive regulation of calcium-independent cell-cell adhesion positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling angiogenesis involved in wound healing cell chemotaxis microglial cell proliferation antimicrobial humoral immune response mediated by antimicrobial peptide neuron cellular homeostasis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion synapse pruning negative regulation of hippocampal neuron apoptotic process negative regulation of glutamate receptor signaling pathway negative regulation of microglial cell activation positive regulation of microglial cell migration negative regulation of neuron migration negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of macrophage chemotaxis platelet activation positive regulation of cell adhesion negative regulation of vasoconstriction negative regulation of cytokine secretion inhibitory postsynaptic potential
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