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CX3CR1 Polyclonal Antibody

查看其他34个CX3CR1抗体

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产品信息

600-401-G89

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
-

免疫组化（石蜡） (IHC (P))

2 µg/mL
-

免疫细胞化学 (ICC/IF)

10-20 µg/mL
-

流式细胞分析 (Flow)

0.1 µg/mL
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CX3CR1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal region of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration an d adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; Cx3c; CX3C chemokine receptor 1; Fractalkine receptor; G-protein coupled receptor 13; Scyd1; unnamed protein product; V28

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基因别名: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; Rbs11; V28

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UniProt ID: (Human) P49238, (Rat) P35411, (Mouse) Q9Z0D9

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Entrez Gene ID: (Human) 1524, (Rat) 171056, (Mouse) 13051

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功能
cytokine receptor activity G-protein coupled receptor activity chemokine receptor activity protein binding G-protein coupled peptide receptor activity C-C chemokine receptor activity C-X3-C chemokine receptor activity C-C chemokine binding C-X3-C chemokine binding CX3C chemokine receptor binding signal transducer activity
参与通路
positive regulation of neuroblast proliferation adaptive immune response microglial cell activation involved in immune response immune system process response to ischemia chemotaxis inflammatory response immune response cellular defense response cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling brain development response to wounding negative regulation of angiogenesis cytokine-mediated signaling pathway calcium-mediated signaling central nervous system maturation leukocyte chemotaxis regulation of tumor necrosis factor production negative regulation of interleukin-1 beta production social behavior autocrine signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of nitric oxide biosynthetic process regulation of synaptic plasticity host-mediated regulation of intestinal microbiota composition regulation of neurogenesis positive regulation of neurogenesis modulation of synaptic transmission leukocyte tethering or rolling positive regulation of protein kinase B signaling synapse maturation cell chemotaxis antifungal innate immune response chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to cytokine stimulus positive regulation of monocyte chemotaxis synapse pruning negative regulation of hippocampal neuron apoptotic process multiple spine synapse organization, single dendrite regulation of microglial cell migration negative regulation of microglial cell mediated cytotoxicity negative regulation of apoptotic signaling pathway microglial cell activation negative regulation of chronic inflammatory response to non-antigenic stimulus memory cerebral cortex cell migration negative regulation of cell migration positive regulation of angiogenesis macrophage chemotaxis cellular response to transforming growth factor beta stimulus negative regulation of long-term synaptic potentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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