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Invitrogen
CXC-ELR Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-58953
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4SP
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Lilly patent anti-Pan-ELR+.
靶标信息
CXC chemokines are a subgroup of the chemokine superfamily distinguished by the presence of a C-X-C motif, where "X" is any amino acid, and they play pivotal roles in immune responses by guiding the migration of leukocytes. A critical subset of these chemokines contains the glutamic acid-leucine-arginine (ELR) motif, which significantly influences angiogenesis and immune cell recruitment. These ELR+ CXC chemokines, including CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8, primarily bind to CXCR1 and CXCR2 receptors. These receptor-ligand interactions activate intracellular signaling pathways essential for neutrophil chemotaxis, tumorigenesis, and wound healing. The structural basis of these interactions and their biological implications, including their roles in pathological conditions such as cancer and inflammatory diseases, have been extensively studied, highlighting their significance in therapeutic targeting.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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