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Invitrogen
CXCL10 Polyclonal Antibody, Biotin, PeproTech®
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CXCL10 Antibody (500-P93BT-25UG) in WB
Western Blot: To detect hIP-10 by Western Blot analysis CXCL10 Polyclonal Antibody, Biotin (Product # 500-P93BT-500UG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hIP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P93BT-25UG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived Recombinant Human IP-10 (CXCL10)
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
AA Sequence of recombinant protein: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IP-10 (CXCL10). Anti-Human IP-10 (CXCL10)-specific antibody was purified by affinity chromatography and then biotinylated.
Sandwich ELISA: To detect hIP-10 by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.25-1.0 µg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human IP-10 (500-P93) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant hIP-10.
Western Blot: To detect hIP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hIP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
500-P93BT-1MG will be provided as 2 x 500 µg
靶标信息
IP-10 (interferon-gamma induced protein 10 kD; in mouse, also called cytokine responsive gene 2, Crg-2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 10 kDa interferon gamma-induced protein; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 10; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 10; CXC; CXC motif chemokine; CXCL; gamma IP10; Gamma-IP10; H-IP-10; interferon-inducible cytokine IP-10; M-IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10
基因别名: C7; crg-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10
UniProt ID: (Human) P02778
Entrez Gene ID: (Human) 3627
chemotaxis
inflammatory response
immune response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
muscle organ development
blood circulation
positive regulation of cell proliferation
response to cold
response to gamma radiation
T cell chemotaxis
regulation of T cell chemotaxis
response to auditory stimulus
negative regulation of angiogenesis
positive regulation of cAMP metabolic process
response to vitamin D
cellular response to heat
endothelial cell activation
regulation of cell proliferation
positive regulation of cAMP-mediated signaling
negative regulation of myoblast differentiation
regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of release of sequestered calcium ion into cytosol
defense response to virus
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
positive regulation of monocyte chemotaxis
regulation of endothelial tube morphogenesis
negative regulation of myoblast fusion
positive regulation of T cell migration
