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Invitrogen

CXCL12 Polyclonal Antibody

查看其他26个CXCL12抗体

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CXCL12 Polyclonal Antibody

产品信息

PA5-119655

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

流式细胞分析 (Flow)

1:50-1:100
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein within human CXCL12 aa 22-93.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2913228

产品详细信息

Positive Control: Hela, rat brain tissue, mouse small intestine tissue, HepG2.

Subcellular Location: Secreted.

靶标信息

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AI174028; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) ligand 12; CXC; CXC motif chemokine; CXCL; CXCL12; hIRH; hSDF-1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; SDF-1 delta; chemokine (C-X-C motif) ligand 12 transcript variant 5; SDF-1 epsilon; chemokine (C-X-C motif) ligand 12 transcript variant 6; SDF-1 gamma; chemokine (C-X-C motif) ligand 12 transcript variant 4; SDF-1 theta; chemokine (C-X-C motif) ligand 12 transcript variant 7; SDF-1a; SDF-1b; SDF1a; stromal cell-derived factor-1 alpha; TLSF-a; TLSF-b; Tlsfa; Tlsfb; unnamed protein product

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基因别名: IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

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UniProt ID: (Human) P48061

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Entrez Gene ID: (Human) 6387

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功能
receptor binding integrin binding protein binding chemokine activity chemokine receptor binding CXCR chemokine receptor binding
参与通路
response to hypoxia neuron migration positive regulation of endothelial cell proliferation cellular calcium ion homeostasis chemotaxis defense response immune response cell adhesion signal transduction G-protein coupled receptor signaling pathway axon guidance blood circulation regulation of actin polymerization or depolymerization positive regulation of cell proliferation adult locomotory behavior response to mechanical stimulus response to virus T cell chemotaxis telencephalon cell migration positive regulation of cell migration organ regeneration killing of cells of other organism positive regulation of dopamine secretion integrin activation chemokine (C-X-C motif) ligand 12 signaling pathway CXCL12-activated CXCR4 signaling pathway response to peptide hormone positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of axon extension involved in axon guidance positive regulation of chemotaxis induction of positive chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain regulation of calcium ion transport cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of calcium ion import negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of leukocyte tethering or rolling positive regulation of vasculature development response to ultrasound cellular response to chemokine positive regulation of T cell migration negative regulation of dendritic cell apoptotic process
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