Invitrogen

CXCL12 alpha (SDF-1 alpha) Polyclonal Antibody, eBioscience™

9个已发表图片
16 篇参考文献
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产品信息

14-7992-81

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

-
查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:500
查看2篇已发表文章 2篇已发表文章

免疫组化（冰冻） (IHC (F))

1:100-1:500
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

-
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酶联免疫吸附实验 (ELISA)

-
查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

1:300-1:500
-
产品规格

种属反应

Mouse, Rat

已发表种属

C. elegans, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_468513

产品详细信息

Description: The polyclonal antibody reacts with both mouse and rat SDF-1 alpha. It was was generated using E. coli-expressed N terminal amio acids 20-89 of mouse SDF-1 alpha as an immunogen. SDF-1 alpha (stromal cell-derived factor-1 alpha), also known as pre-B-cell growth-stimulating factor (PBSF), is a 70-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of the SDF-1 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis. SDF-1 has been shown to be chemotactic for lymphocytes. In addition, SDF-1 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV-1 entry.

Applications Reported: This polyclonal has been reported for use in immunoblotting (WB), immunoprecipitation, and immunohistochemistry. Cross-reactivity to SDF-1 alpha of other species has not been determined.

Applications Tested: To achieve best results, titrate antibody by dilution for each application as follows:

Western Blot 1:1000

Immunoprecipitation 1:300-500

Immunohistochemistry 1:100-500.

Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; CXCL; H-SDF-1-alpha; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF 1 a; SDF 1 alpha; SDF 1α; SDF-1; SDF-1 gamma; SDF1 alpha; SDF1α; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; stromal cell-derived factor-1 gamma; Thymic lymphoma cell-stimulating factor; TLSF; TPAR1

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基因别名: Cxcl12; Pbsf; Scyb12; Sdf1; Tlsf; Tpar1

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UniProt ID: (Mouse) Q4FJL5

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Entrez Gene ID: (Rat) 24772, (Mouse) 20315

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