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Invitrogen
CXCL3 Polyclonal Antibody
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CXCL3 Antibody (PA5-47704) in Neu
Neutralization of CXCL3 in BaF3 mouse pro‚B cell line transfected with human CXCR2. Samples were incubated in CXCL3 polyclonal antibody (Product # PA5-47704). Recombinant Rat CXCL3/CINC‚2α chemoattracts the BaF3 mouse pro‚B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Rat CXCL3/CINC‚2α (0.05 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Rat... View More
产品信息
PA5-47704
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant rat CXCL3/CINC-2 alpha/beta Arg33-Ser100
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, greater than 50% cross-reactivity with recombinant rat (rr) CINC-1, rrCINC-2 beta, and rrCINC-3 is observed, less than 25% cross-reactivity with recombinant mouse (rm) KC, rmMIP-2, recombinant human (rh) GRO alpha, rhGRO beta, and rhGRO gamma is observed, and less than 10% cross-reactivity with rhIL-8 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
CXCL3 may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 3; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; gro gamma; macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
基因别名: Cinc-2; Cinc2; Gm1960
Entrez Gene ID: (Rat) 171551
positive regulation of leukocyte chemotaxis
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
hemopoiesis
neutrophil chemotaxis
response to lipopolysaccharide
regulation of cell proliferation
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
